Shelley describes how an unfortunate chop stick through the eye facillitated the collection and subsequent culture of neural stem cells from the prefrontal subcortex.
A Chinese woman was admitted to Huashan Hospital in Shanghai, with a chopstick in her brain (!)—specifically the inferior prefrontal subcortex. The chopstick was removed by a Dr. Zu, who took the opportunity to culture the brain tissue that came out with the chopstick. [...]
The cultured tissue thrived, and many of the resultant cells contained proteins that were characteristic of neural stem cells. In order to make sure they were really stem cells, Dr. Zu cultured cells in isolation and watch and see if it divides into daughter cells. He found that about 4% of the ‘chopstick cells’ went on to form neurospheres (a ball of daughter cells), indicating that they were stem cells.
Jumping ahead…
They transplanted cultured neural stem cells derived from 8 patients with brain injuries back into those same patients’ brains. They then asked a separate group of neurologists to blindly examine these experimental patients and compare them with un-treated control patients who also had similar injuries. The treated patients had lower disability scores (a good thing), possibly paving the way for this therapy to be used clinically. And all because of one mis-aimed chopstick!
I haven’t been able to find any peer reviewed references on this latter paragraph, and would appreciate if anyone could point me in the right direction. There’s a review by Zhu and colleagues here (PDF), and a mention by Seed magazine. China’s seemingly prodigous status in stem cell research is interesting in itself.
(Pretty confocal photomicrograph from here.)